AustralieFrV1, Main, Exploration, bibRecord, 006449

Effect of clopidogrel plus ASA vs. ASA early after TIA and ischaemic stroke: a substudy of the CHARISMA trial

Identifieur interne : 006449 ( Main/Exploration ); précédent : 006448; suivant : 006450

Effect of clopidogrel plus ASA vs. ASA early after TIA and ischaemic stroke: a substudy of the CHARISMA trial

Auteurs : Graeme J. Hankey [Australie] ; S. Claiborne Johnston [États-Unis] ; J. Donald Easton [États-Unis] ; Werner Hacke [Allemagne] ; Jean-Louis Mas [France] ; Danielle Brennan [États-Unis] ; Koon Hou Mak [Singapour] ; Deepak L. Bhatt [États-Unis] ; Keith A. A. Fox [Royaume-Uni] ; Eric J. Topol [États-Unis]

Source :

International Journal of Stroke [ 1747-4930 ] ; 2011-02.

RBID : ISTEX:D69DC0871888C0B2F7EAF5CE91169BEF8A65C3F6

English descriptors

Abstract

Background The Clopidogrel for High Atherothrombotic Risk and Ischaemic Stabilisation, Management and Avoidance (CHARISMA) trial reported no statistically significant benefit of adding clopidogrel to acetylsalicylic acid in the long‐term management of a broad population of patients with stable vascular disease. However, a subanalysis raised the hypothesis that dual antiplatelet therapy with clopidogrel plus acetylsalicylic acid may be more effective than aspirin in patients with prior ischaemic stroke, myocardial infarction of symptomatic peripheral arterial disease. We aimed to determine whether the possible benefits of clopidogrel plus acetylsalicylic acid in patients with transient ischaemic attack and ischaemic stroke may be ‘front‐loaded’, and maximal within the first 30‐days of randomisation, without being unduly hazardous.

Url:

https://api.istex.fr/document/D69DC0871888C0B2F7EAF5CE91169BEF8A65C3F6/fulltext/pdf

DOI: 10.1111/j.1747-4949.2010.00535.x

Affiliations:

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Le document en format XML

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<term>Acetylsalicylic</term>
<term>Acetylsalicylic acid</term>
<term>Antiplatelet therapy</term>
<term>Arterial origin</term>
<term>Aspirin</term>
<term>Astra zeneca</term>
<term>Atherothrombotic</term>
<term>Boehringer ingelheim</term>
<term>Bristol myers squibb</term>
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<term>Confidence intervals</term>
<term>Consulting fees</term>
<term>Early recurrence</term>
<term>February</term>
<term>Final version</term>
<term>Haemorrhage</term>
<term>Haemorrhagic stroke</term>
<term>Hankey</term>
<term>Hazard ratio</term>
<term>High atherothrombotic risk</term>
<term>International journal</term>
<term>Intracerebral haemorrhage</term>
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<term>Ischaemic stabilisation</term>
<term>Ischaemic stroke</term>
<term>Lancet neurol</term>
<term>Medicines company</term>
<term>Myocardial infarction</term>
<term>Patients randomised</term>
<term>Placebo</term>
<term>Primary outcome</term>
<term>Primary outcome measure</term>
<term>Prognostic data</term>
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<term>Relative risk reduction</term>
<term>Sanofi aventis</term>
<term>Significant difference</term>
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<front><div type="abstract">Background The Clopidogrel for High Atherothrombotic Risk and Ischaemic Stabilisation, Management and Avoidance (CHARISMA) trial reported no statistically significant benefit of adding clopidogrel to acetylsalicylic acid in the long‐term management of a broad population of patients with stable vascular disease. However, a subanalysis raised the hypothesis that dual antiplatelet therapy with clopidogrel plus acetylsalicylic acid may be more effective than aspirin in patients with prior ischaemic stroke, myocardial infarction of symptomatic peripheral arterial disease. We aimed to determine whether the possible benefits of clopidogrel plus acetylsalicylic acid in patients with transient ischaemic attack and ischaemic stroke may be ‘front‐loaded’, and maximal within the first 30‐days of randomisation, without being unduly hazardous.</div>
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Effect of clopidogrel plus ASA vs. ASA early after TIA and ischaemic stroke: a substudy of the CHARISMA trial

Effect of clopidogrel plus ASA vs. ASA early after TIA and ischaemic stroke: a substudy of the CHARISMA trial

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri